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Manipulating both the inhibitory and stimulatory immune system towards the success of therapeutic vaccination against chronic viral infections

โœ Scribed by Sang-Jun Ha; Erin E. West; Koichi Araki; Kendall A. Smith; Rafi Ahmed

Book ID
111248879
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
538 KB
Volume
223
Category
Article
ISSN
0105-2896

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๐Ÿ“œ SIMILAR VOLUMES

Therapeutic vaccination against chronic
Therapeutic vaccination against chronic viral infection: the importance of cooperation between CD4+ and CD8+ T cells
โœ Allan J Zajac; Kaja Murali-Krishna; Joseph N Blattman; Rafi Ahmed ๐Ÿ“‚ Article ๐Ÿ“… 1998 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 740 KB

The goal of therapeutic vaccination is to elicit an antiviral immune response within persistently infected individuals and consequently eradicate the infection. CD8+ T cells are potent mediators of viral clearance; however, during chronic infections CD4+ T cell help is required to sustain antiviral