𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Therapeutic vaccination against chronic viral infection: the importance of cooperation between CD4+ and CD8+ T cells

✍ Scribed by Allan J Zajac; Kaja Murali-Krishna; Joseph N Blattman; Rafi Ahmed

Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
740 KB
Volume
10
Category
Article
ISSN
0952-7915

No coin nor oath required. For personal study only.

✦ Synopsis

The goal of therapeutic vaccination is to elicit an antiviral immune response within persistently infected individuals and consequently eradicate the infection. CD8+ T cells are potent mediators of viral clearance; however, during chronic infections CD4+ T cell help is required to sustain antiviral CD8+ T cell activity. Therapeutic vaccination should be targeted towards enhancing both CD4+ and CD8+ T cell virus-specific responses.

πŸ“œ SIMILAR VOLUMES

Cytokine-dependent anti-viral role of CD
Cytokine-dependent anti-viral role of CD4-positive T cells in therapeutic vaccination against chronic hepatitis B viral infection
✍ Fenyu Ren; Keisuke Hino; Yuhki Yamaguchi; Kiyomi Funatsuki; Akio Hayashi; Hiroak πŸ“‚ Article πŸ“… 2003 πŸ› John Wiley and Sons 🌐 English βš– 210 KB

## Abstract There are several lines of evidence suggesting that specific vaccine therapy with a standard hepatitis B virus (HBV) vaccination reduces HBV replication. The aim of this study was to investigate the anti‐viral mechanism of vaccine therapy in chronic hepatitis B patients. Nineteen patien

The role of CD4 and CD8 T cells in viral
The role of CD4 and CD8 T cells in viral infections
✍ Ulrich H Koszinowski; Matthias J Reddehase; Stipan Jonjic πŸ“‚ Article πŸ“… 1991 πŸ› Elsevier Science 🌐 English βš– 772 KB

Presentation of viral antigens to T cells does not require uptake by 'professional' antigen-presenting cells. Viruses have specialized to enter the cells in which they replicate. Virus entry, uncoating and new viral protein synthesis can load both the cytosolic and the endosomal pathway of antigen p

The Dual Role of CD4 T Helper Cells in t
The Dual Role of CD4 T Helper Cells in the Infection Dynamics of HIV and Their Importance for Vaccination
✍ H. KORTHALS ALTES; D. WODARZ; V.A.A. JANSEN πŸ“‚ Article πŸ“… 2002 πŸ› Elsevier Science 🌐 English βš– 218 KB

Given the role of the CD4 T helper cells in the development of memory CTL precursors, it seems bene"cial to boost the CD4 T helper response in the context of vaccination against the human immunode"ciency virus (HIV). However, CD4 T cells are also the preferred targets of infection by HIV. Here, we a