Therapeutic targeting of the p53 tumor suppressor gene
โ Scribed by Gary A Beaudry; Arthur H Bertelsen; Michael I Sherman
- Book ID
- 108476251
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 877 KB
- Volume
- 7
- Category
- Article
- ISSN
- 0958-1669
No coin nor oath required. For personal study only.
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Transgenic mice deficient for the p53 gene were reported to frequently develop angiosarcoma (AS), suggesting that alterations in the gene are associated with tumorigenesis of AS. However, little is known about genetic changes, including p53 gene alterations, in human AS because of its rarity. We ana
The tumor-suppressor gene product p53 is clearly a component in several biochemical pathways, including transcription, DNA repair, genomic stability, cell-cycle control and apoptosis, that are central to human carcinogenesis. The p53 is functionally inactivated by mutational, viral, and cellular mec