Targeting the p53 tumor suppressor gene function in glioblastomas using small chemical molecules

Deletion of the p53 tumor suppressor gen

Deletion of the p53 tumor suppressor gene improves neuromotor function but does not attenuate regional neuronal cell loss following experimental brain trauma in mice

✍ Gregor Tomasevic; Ramesh Raghupathi; Uwe Scherbel; Tadeusz Wieloch; Tracy K. McI 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 292 KB

## Abstract Deletion of the tumor suppressor gene p53 has been shown to improve the outcome in experimental models of focal cerebral ischemia and kainate‐induced seizures. To evaluate the potential role of p53 in traumatic brain injury, genetically modified mice lacking a functional p53 gene (p53^–