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Therapeutic studies in NZB/NZW mice.

✍ Scribed by Alfred D. Steinberg; Randall Krakauer; James L. Reinertsen; Lynell W. Klassen; David Ilfeld; J. Patton Reeves; Gary W. Williams; Tatiana Antonovych


Publisher
John Wiley and Sons
Year
1978
Tongue
English
Weight
498 KB
Volume
21
Category
Article
ISSN
0004-3591

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## Abstract NZB/NZW F~1~ female mice received levamisole in an attempt to increase suppressor T cell function. Responses varied with dosage of drug and age of mice. When treatment with 25 ΞΌg/gm doses (intermittent or daily) was begun at 12 weeks of age, nephritis was accelerated in spite of transie

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## Abstract Prepubertal castration of female NZB/NZW (B/W) hybrid mice did not influence mortality, whereas prepubertal castration of male B/W mice caused premature death and enhanced autoantibody formation. Prepubertal castration combined with the administration of sustained estradiol‐17‐β (E‐2) e