Prostaglandin E1 treatment of NZB/NZW mice
β Scribed by Robert B. Zurier; Donna M. Sayadoff; Susan B. Torrey; Naomi F. Rothfield
- Publisher
- John Wiley and Sons
- Year
- 1977
- Tongue
- English
- Weight
- 733 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0004-3591
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract NZB/NZW F~1~ female mice received levamisole in an attempt to increase suppressor T cell function. Responses varied with dosage of drug and age of mice. When treatment with 25 ΞΌg/gm doses (intermittent or daily) was begun at 12 weeks of age, nephritis was accelerated in spite of transie
## Proliferation of Ly-1 B cells in autoimmune NZB and (NZB X NZW)F1 mice* Spontaneous autoimmune disease in NZB and (NZB x NZW)FI (B/W) mice is associated with a spectrum of lymphoproliferative abnormalities, but the relationship between autoimmunity and lymphoproliferation is poorly understood.
## Abstract Prepubertal castration of female NZB/NZW (B/W) hybrid mice did not influence mortality, whereas prepubertal castration of male B/W mice caused premature death and enhanced autoantibody formation. Prepubertal castration combined with the administration of sustained estradiolβ17βΞ² (Eβ2) e
performed to determine whether endogenous lymphoid tissue concentrations of prostaglandins also vary as a function of age, sex, and genetic susceptibility to autoimmunc disease.