Alteration of lymphocyte function in nzb/nzw mice

✍ Scribed by Dr. Bevra H. Hahn; Linda L. Knotts

• Publisher: John Wiley and Sons
• Year: 1979
• Tongue: English
• Weight: 535 KB
• Volume: 22
• Category: Article
• ISSN: 0004-3591
• DOI: 10.1002/art.1780220305

✦ Synopsis

Abstract

NZB/NZW F~1~ female mice received levamisole in an attempt to increase suppressor T cell function. Responses varied with dosage of drug and age of mice. When treatment with 25 μg/gm doses (intermittent or daily) was begun at 12 weeks of age, nephritis was accelerated in spite of transient reduction of anti‐DNA antibodies. When treatment was begun at 4 weeks, or when doses of 250 μg/gm were given, no clinical effects were observed. In the mice with accelerated disease, delayed hypersensitivity and antibody responses to sheep erythrocytes increased; antibody responses to pneumococcal poiysaccharide were unaffected. It is possible that some increased immune responses associated with levamisole are undesirable in murine lupus.