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Therapeutic effects of liposomal adriamycin in combination with tumor necrosis factor-α

✍ Scribed by Yuji Maruo; Hiroyuki Konno; Shozo Baba

Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
630 KB
Volume
49
Category
Article
ISSN
0022-4790

No coin nor oath required. For personal study only.

✦ Synopsis

Liposomes as drug carriers in cancer chemotherapy have attracted considerable interest. To enhance the therapeutic effect of Adriamycin entrapped in liposomes (Lip-ADM) on human solid tumors, we investigated the therapeutic effects of Lip-ADM in combination with recombinant human tumor necrosis factor-a (rTNF-a), which is known to have specific effects on tumor vasculature. rTNF-a or saline solution was injected intravenously into nude mice bearing a human colon cancer strain, HC-I , at 1 hour before intravenous administration of Lip-ADM. The significant therapeutic effect of Lip-ADM in combination with rTNF-a was demonstrated by the evaluation with tumor growth curve and the actual tumor weights, in comparison with groups of mice treated with saline solution, rTNF-a alone, or with a Lip-ADM after saline. Levels of Adriamycin in tumor tissue in the Lip-ADM in combination with rTNF-a-treated group were higher than those in Lip-ADM with saline solution-treated group.

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