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Anti-tumor effects of tumor necrosis factor alone or combined with radiotherapy

✍ Scribed by Gregor Sersa; Veronica Willingham; Luka Milas

Publisher
John Wiley and Sons
Year
1988
Tongue
French
Weight
651 KB
Volume
42
Category
Article
ISSN
0020-7136

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✦ Synopsis

Recombinant human tumor necrosis factor (rHuTNF) was investigated for its ability to increase the response of murine tumors to ionizing radiation. Both multiple i.v. administrations of rHuTNF and local tumor irradiation caused a significant delay in tumor growth. The effect of treatment with both agents combined was greater than the additive effect of the individual treatments. Furthermore, rHuTNF significantly increased tumor radiocurability, as assessed by the TCDSO assay. rHuTNF was not cytotoxic to tumor cells, nor did it affect their radiosensitivity. The in viva anti-tumor effect of rHuTNF and its augmentation of tumor radioresponse were mediated through indirect mechanisms, either immunological or non-immunological. rHuTNF was also effective in reducing the damaging effect of ionizing radiation on bone-marrow progenitor cells, which could increase the therapeutic advantage of the rHuTNF-radiotherapy combination. These experiments suggest that rHuTNF is potentially beneficial in combination with radiotherapy.

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