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Therapeutic benefit of intrathecal injection of insulin-like growth factor-1 in a mouse model of Amyotrophic Lateral Sclerosis

✍ Scribed by Isao Nagano; Hristelina Ilieva; Mito Shiote; Tetsuro Murakami; Masataka Yokoyama; Mikio Shoji; Koji Abe


Book ID
119301727
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
342 KB
Volume
235
Category
Article
ISSN
0022-510X

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Therapeutic benefits of intrathecal prot
✍ Yasuyuki Ohta; Tatsushi Kamiya; Makiko Nagai; Tetsuya Nagata; Nobutoshi Morimoto πŸ“‚ Article πŸ“… 2008 πŸ› John Wiley and Sons 🌐 English βš– 589 KB

## Abstract When fused with the protein transduction domain (PTD) derived from the human immunodeficiency virus TAT protein, proteins can cross the blood–brain barrier and cell membrane and transfer into several tissues, including the brain, making protein therapy feasible for various neurological