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Impaired expression of insulin-like growth factor-1 system in skeletal muscle of amyotrophic lateral sclerosis patients

✍ Scribed by Christian Lunetta; Massimo Serafini; Alessandro Prelle; Paolo Magni; Elena Dozio; Massimiliano Ruscica; Jenny Sassone; Clarissa Colciago; Maurizio Moggio; Massimo Corbo; Vincenzo Silani

Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
741 KB
Volume
45
Category
Article
ISSN
0148-639X

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## Abstract ## Objective To determine the role of insulin‐like growth factor binding protein 3 (IGFBP‐3) in mediating the effects of transforming growth factor β (TGFβ) on tenascin‐C (TN‐C) production and to assess the levels of TN‐C in vivo in patients with systemic sclerosis (SSc)–associated pul