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Theoretical Study of N -Demethylation of Substituted N,N -Dimethylanilines by Cytochrome P450: The Mechanistic Significance of Kinetic Isotope Effect Profiles

✍ Scribed by Wang, Yong; Kumar, Devesh; Yang, Chuanlu; Han, Keli; Shaik, Sason


Book ID
124049023
Publisher
American Chemical Society
Year
2007
Tongue
English
Weight
754 KB
Volume
111
Category
Article
ISSN
0022-3654

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Lignin peroxidase catalyses the oxidative N-demethylation of ring-substituted N,N-dimethylanilines by an electrontransfer mechanism whereby an anilinium radical cation is formed which is then deprotonated by the enzyme. Information on the nature of the basic centre which deprotonates the radical cat