Isotope-Effect Profiles in the Oxidative N-Demethylation of N,N-Dimethylanilines Catalysed by Lignin Peroxidase and a Chemical Model
✍ Scribed by Enrico Baciocchi; M. Francesca Gerini; Osvaldo Lanzalunga; Andrea Lapi; Maria Grazia Lo Piparo; Simona Mancinelli
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- English
- Weight
- 270 KB
- Volume
- 2001
- Category
- Article
- ISSN
- 1434-193X
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✦ Synopsis
Lignin peroxidase catalyses the oxidative N-demethylation of ring-substituted N,N-dimethylanilines by an electrontransfer mechanism whereby an anilinium radical cation is formed which is then deprotonated by the enzyme. Information on the nature of the basic centre which deprotonates the radical cation has been obtained by determining the KDIE profile (plot of k H /k D vs. the pK a of the aniline radical cations) for a number of ring-substituted N,N-bis(dideuteriomethyl)anilines. From the bell-shaped curve it has been estimated