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Thebaine Cyclopropanation.

โœ Scribed by E. E. Schultz; M. M. Shakirov; I. Yu. Bagryanskaya; Yu. V. Gatilov; G. A. Tolstikov; V. N. Kalinin; H. Schmidhammer


Publisher
John Wiley and Sons
Year
2005
Weight
18 KB
Volume
36
Category
Article
ISSN
0931-7597

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๐Ÿ“œ SIMILAR VOLUMES


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## Study on Synthesis of Thebaine Derivatives LIU, He\*(ๅˆ˜ๆฒณ) LIU, Chun-He(ๅˆ˜ๆ˜ฅๆฒณ) WU, Bo(ๅดๆณข) ZHONG, Bo-Hua(ไปฒไผฏๅŽ) GONG, Ze-Hui(ๅฎซๆณฝ่พ‰)

The synthesis of thebaine-1-3H
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A synthesis of thebaine is described where the C-1 position is labelled with tritium to specific activity of 16 Ci/mmole. From codeine (a, 1iodocodeine ( 1 ) was prepared and converted to 1-iodothebaine (T, in 3 steps. The subsequent key reaction was the selective hydrogenolysis of the carbon-iodine