Thebaine Cyclopropanation.
โ Scribed by E. E. Schultz; M. M. Shakirov; I. Yu. Bagryanskaya; Yu. V. Gatilov; G. A. Tolstikov; V. N. Kalinin; H. Schmidhammer
- Publisher
- John Wiley and Sons
- Year
- 2005
- Weight
- 18 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0931-7597
No coin nor oath required. For personal study only.
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Bei der Offnung des Piperidinringes im Thebain mit Acetyl-und Benzoylchlorid sowie Chlorameisensaure-athylund -benzylester in feuchtem Xthykdcetat entstehen die entsprechenden Codeinon-acyl-normethine (1 a-1 d), die je nach Katalyse interessante Umlagerungsund Spaltungsreaktionen eingehen. Durch Ums
## Study on Synthesis of Thebaine Derivatives LIU, He\*(ๅๆฒณ) LIU, Chun-He(ๅๆฅๆฒณ) WU, Bo(ๅดๆณข) ZHONG, Bo-Hua(ไปฒไผฏๅ) GONG, Ze-Hui(ๅฎซๆณฝ่พ)
A synthesis of thebaine is described where the C-1 position is labelled with tritium to specific activity of 16 Ci/mmole. From codeine (a, 1iodocodeine ( 1 ) was prepared and converted to 1-iodothebaine (T, in 3 steps. The subsequent key reaction was the selective hydrogenolysis of the carbon-iodine