The αβ T-cell receptor heterodimer: crystal clear at last

• Book ID: 104298825
• Publisher: Elsevier Science
• Year: 1996
• Tongue: English
• Weight: 193 KB
• Volume: 17
• Category: Article
• ISSN: 0167-5699
• DOI: 10.1016/s0167-5699(97)84207-7

✦ Synopsis

Although the (Y and l3 chains of the T-cell receptor (TCR) have been separately crystallized', a crystal structure for an intact, correctly folded heterodimer has previously been elusive. Prior attempts to get correctly paired TCR heterodimers to crystallize appear to have fallen foul of subtle aberrations in glycosylation during expression-.

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