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The why and how of thymocyte negative selection

✍ Scribed by Owen Marc Siggs; Lydia Elizabeth Makaroff; Adrian Liston


Book ID
108099518
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
371 KB
Volume
18
Category
Article
ISSN
0952-7915

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Considerable evidence suggests that the ERK pathway is required for positive but not negative thymocyte selection. Here, we report that ERK is highly activated in double-positive (DP) thymocytes expressing an MHC class I-restricted TCR (P14) in response to negatively selecting conditions, whereas li