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Cellular and biochemical requirements for thymocyte negative selection

โœ Scribed by Dawne M. Page; Lawrence P. Kane; Thandi M. Onami; Stephen M. Hedrick


Book ID
115647814
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
168 KB
Volume
8
Category
Article
ISSN
1044-5323

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Considerable evidence suggests that the ERK pathway is required for positive but not negative thymocyte selection. Here, we report that ERK is highly activated in double-positive (DP) thymocytes expressing an MHC class I-restricted TCR (P14) in response to negatively selecting conditions, whereas li