Degree of ERK activation influences both
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Sanjeev Mariathasan; Shirley S. N. Ho; Arsen Zakarian; Pamela S. Ohashi
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Article
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2000
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John Wiley and Sons
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English
โ 149 KB
Considerable evidence suggests that the ERK pathway is required for positive but not negative thymocyte selection. Here, we report that ERK is highly activated in double-positive (DP) thymocytes expressing an MHC class I-restricted TCR (P14) in response to negatively selecting conditions, whereas li