This study was conducted to comprehensively evaluate the performance of various allometric scaling methods for the prediction of human clearance. Allometric scaling was used to predict clearance for 103 compounds, for which clearance data in the rat, dog, monkey, and humans were available. Allometry
The validation of the intestinal permeability approach to predict oral fraction of dose absorbed in humans and rats
β Scribed by Win L. Chiou
- Publisher
- John Wiley and Sons
- Year
- 1995
- Tongue
- English
- Weight
- 301 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0142-2782
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
The oral bioavailability of tributylmethyl ammonium (TBuMA), an organic cation (OC), exhibited a dose-dependency (i.e., 17, 27, and 35% at doses of 0.4, 4, or 12 micromol/kg, respectively) in the rat. Relevant mechanisms were investigated in the present study by estimating the mucosal to serosal (m-
In Table 3, the MAE value for three-species allometric scaling using the rule of exponents should be 6.44, not 11.03 as originally cited. This error resulted from an incorrect predicted value for one of the 103 compounds in the dataset (nicotine; incorrect error of 479.6 mL/min/kg rather than the co