Species differences in the formation of DA-8164 after intravenous and/or oral administration of DA-8159, a new erectogenic, to mice, rats, rabbits, dogs and humans
β Scribed by Hyun J. Shim; Yu C. Kim; Joo H. Lee; Kyung J. Park; Jong W. Kwon; Won B. Kim; Myung G. Lee
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 91 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0142-2782
- DOI
- 10.1002/bdd.444
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π SIMILAR VOLUMES
Time-averaged total body clearance (Cl) and apparent volume of distribution at steady state (V SS ) of DA-8159 after intravenous administration to mice (30 mg/kg), rats (30 mg/kg), rabbits (30 mg/kg) and dogs (3 mg/kg) were analysed as a function of species body weight (W) using the allometric equat
The pharmacokinetic parameters including tissue distribution and/or biliary excretion of DA-1131, a new carbapenem, were evaluated after intravenous (iv) administration to mice, rats, rabbits, and dogs. After i.v. administration to mice (20, 50, 100, and 200 mg kg-1), rats (50, 100, 200, and 500 mg