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The use of pharmacokinetic and pharmacodynamic data in the assessment of drug safety in early drug development

✍ Scribed by D. K. Walker

Book ID: 108640209
Publisher: John Wiley and Sons
Year: 2004
Tongue: English
Weight: 126 KB
Volume: 58
Category: Article
ISSN: 0306-5251
DOI: 10.1111/j.1365-2125.2004.02194.x

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## Background There have been few reports of pharmacokinetic models that have been linked to models of the cardiovascular system. Such models could predict the cardiovascular effects of a drug under a variety of circumstances. Limiting factors may be the lack of a suitably simple cardiovascular mod