Administration of terfenadine (Seldane@) immediately after a high fat breakfast slightly affects the rate but not the extent of absorption relative to fasting administration. Mean peak levels of the active metabolite were increased by 13 per cent but delayed by 0.9 h while AUC was virtually the same
On the assessment of effects of food on the pharmacokinetics of drugs in early development
β Scribed by Zhihong Li; Nimish N. Vachharajani; Rajesh Krishna
- Publisher
- John Wiley and Sons
- Year
- 2002
- Tongue
- English
- Weight
- 78 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0142-2782
- DOI
- 10.1002/bdd.309
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Bioavailability of avitriptan was found to decrease significantly when administered 5 min after a standard high fat meal. The studies described herein were carried out to gain insight into the mechanism of this food effect. A series of studies were conducted in humans to assess the effect of timing
Casodex' (bicalutamide) is an orally active, non-steroidal, pure antiandrogen; it is a racemate with antiandrogenic activity residing predominantly in the (R)-enantiomer. Healthy male volunteers (n=15) were administered single oral doses of bicalutamide (50 mg) after food and after fasting as part o
An excellent review of the role of MR in drug development was published this year in NMR in Biomedicine, and elegantly expounded upon at the recent 7th Conference of the ISMRM, Philadelphia. 1 The review discussed and presented detailed evidence of the current and potential contribution of NMR to th
The objectives of this study were to assess the effect of food and gender on the pharmacokinetics of avitripan. A group of 12 healthy men and 12 healthy women was administered a single 50 mg dose of avitriptan capsule under fasting conditions and 5 min after a high-fat breakfast. The two treatments