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Absence of food effects on the pharmacokinetics of terfenadine

✍ Scribed by Dr Mark G. Eller; Barbara J. Walker; Lianng Yuh; Kelly K. Antony; Bruce E. McNutt; Richard A. Okerholm

Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
363 KB
Volume
13
Category
Article
ISSN
0142-2782

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✦ Synopsis

Administration of terfenadine (Seldane@) immediately after a high fat breakfast slightly affects the rate but not the extent of absorption relative to fasting administration. Mean peak levels of the active metabolite were increased by 13 per cent but delayed by 0.9 h while AUC was virtually the same as when terfenadine was administered while fasting. Changes in rate of absorption may be due to delayed gastric emptying and more rapid terfenadine solubilization. In any case, these rate differences are unlikely to be clinically important in the absence of differences in extent of absorption.

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