𝔖 Bobbio Scriptorium

✦ LIBER ✦

Accelerating drug development: methodology to support first-in-man pharmacokinetic studies by the use of drug candidate microdosing

✍ Scribed by Matthew A. McLean; Chi-Yan J. Tam; Michael T. Baratta; Christopher L. Holliman; Robert M. Ings; Gerald R. Galluppi

Publisher: John Wiley and Sons
Year: 2007
Tongue: English
Weight: 138 KB
Volume: 68
Category: Article
ISSN: 0272-4391
DOI: 10.1002/ddr.20160

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Acute and Chronic Toxicity of Veratrum V

Acute and Chronic Toxicity of Veratrum Viride††The Veratrum viride studied was the whole-powdered drug marketed by Irwin, Neisler & Co. under the name, Vertavis. The work reported herein was supported by a grant from this firm. The batch of powder used in these experiments was stated by the manufacturer to have been assayed biologically by the Craw method on Daphnia magna. One Craw unit of the material studied was stated to be 15.6mg. With regard to this assay, Mr. R. O. Craw has been so kind as to allow us to publish a brief explanation: A reference lot of Yerolrum oirid; powder was set-aside as a standard and a 10% w/v aqueous extract was made of this powder. The average median length of life in 50 assays of 1000 daphnia on immersion in the solution was determined to be 2.22 hours. The daphnia were considered dead when the heart was found to be in systolic standstill on microscopic examination. Succeeding lots of powder were assayed and their potency determined by relating the median length of life of daphnia to 2.22 hours, which is one unit. Twenty assays of 10 animals each were used on each lot of powder.‡‡The authors wish to thank Dr. J. F. A.,McManus of the Department of Pathology for a pathologic report on the tissues, and Mr. James Thomas and Mrs. Bobby E. Teague for technical assistance.

✍ Perdue, Adoline S. ;Bell, Frances ;Starnes, W.R. ;Hitchcock, Philip ;Teague, R.S 📂 Article 📅 1950 🏛 Elsevier ⚖ 346 KB 👁 1 views

The cultivation of hydrastis**This artic

The cultivation of hydrastis**This article is written in the first person, and, by request of the editor, gives facts concerning Hydrastis culture as observed in my own experimentations, corroborated by others known to me personally. No attempt has therefore been made to embody the experiences of persons who have heretofore printed articles on the subject, nor have my own previous publications, or my own photographs and detail notes'been used at all, excepting briefly. The cuts, excepting those showing the Hydrastis farm of Dr. Homsher, are from Drugs and Medicines of North America, 1884, or from others of my previous prints on the subject. The object being to present the problem so as to save to others experimental wanderings, I must yet urge the reader who proposes to enter the field of Hydrastis culture, to study carefully the Bulletins issued OR this subject by the Agricultural Department of the United States Government, especially the admirable pamphlet of Miss Alice Henkel and G. Fred Klugh, of the Bweau of Plant Industry.-L.

✍ Lloyd, John Uri 📂 Article 📅 1912 🏛 Elsevier ⚖ 706 KB