## Abstract __N__‐protected peptides, which are important intermediates as a carboxyl component in the fragment condensation method, have been prepared in high yields by the reaction of __o__‐nitrophenylsulfenyl (Nps) __N__‐carboxy α‐amino acid anhydrides with unprotected peptides and amino acids i
The Use of o-Nitrophenylsulfenyl-N-Carboxyanhydrides in N-Hydroxypeptide Synthesis
✍ Scribed by Prof. Dr. A. Chimiak; Dr. T. PołOṅSki
- Publisher
- John Wiley and Sons
- Year
- 1980
- Tongue
- English
- Weight
- 339 KB
- Volume
- 322
- Category
- Article
- ISSN
- 1615-4150
No coin nor oath required. For personal study only.
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## Abstract __N__‐Urethane‐protected __N__‐carboxyanhydrides (UNCAs) are very reactives. They have been successfully used in peptide synthesis, in both solution and solid phase. We have demonstrated that UNCAs are interesting starting materials for the synthesis of various amino acid derivatives. C
N-Trityl-and N-Phenylfluorenyl-N-carboxyanhydrides and Their Use in Dipeptide Synthesis. -Heating of title compounds like (IV) and (XI) with amino acids in THF leads to dipeptides in good yields with complete enantiomeric integrity. In the presence of KCN as well as NaN 3 significant epimerization
## Abstract 2‐Thiopyridone (2‐mercaptopyridine, **1**) was found to be a very suitable reagent for removing the __N__^α^‐o‐nitrophenylsulfenyl (NPS‐) group in both conventional and solid‐support peptide synthesis. A 3‐ to 5‐molar excess of the reagent together with an equivalent amount of glacial a