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The use of naphthalene-2,3-dicarboxaldehyde for the analysis of primary amines using high-performance liquid chromatography and capillary electrophoresis

✍ Scribed by Georges Rammouz; Marlène Lacroix; Jean Christophe Garrigues; Véréna Poinsot; François Couderc

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
351 KB
Volume
21
Category
Article
ISSN
0269-3879

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✦ Synopsis

Abstract

This paper reviews analytical methods, instrumental developments and applications for derivatization of primary amines with naphthalene‐2,3‐dicarboxaldehyde using fluorescence and chemiluminescence detection with capillary electrophoresis (CE) and high performance liquid chromatography (HPLC). The use of lasers as well as lamps as the excitation source for fluorescence detection is discussed. The detection limit observed with naphthalene‐2,3‐dicarboxaldehyde derivatization is often lower and better than those obtained with other analytical separations and other fluorescent dyes. In addition, this paper describes the crucial points that influence the stability of NDA primary amine derivatives, and summarize the separation, derivatization and migration conditions of the different techniques, with their advantages and drawbacks. Copyright © 2007 John Wiley & Sons, Ltd.

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