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The use of n-ethylbenzisoxazolium cation for the cyclization of peptides

โœ Scribed by S. Rajappa; A.S. Akerkar

Book ID
104250313
Publisher
Elsevier Science
Year
1966
Tongue
French
Weight
155 KB
Volume
7
Category
Article
ISSN
0040-4039

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โœฆ Synopsis

Yooduard and Kmp have noemtl~ introduced the I-rthylbennrlaoxmollua cation a# a r-gent for peptldo coupling', The reaction proceeda in two dlwrete atagea, the first Involy'Ang the formation of an 8ctive eater, and the second, its coupling with the amine component: \ R-aoOR + a")" :I -c21$ _3 R-co.0 0 9 ,-, IV-RR2 .BR.C~ ; R-CO-If&R' + l Oontrlbutlon Ro.49fmm CIRA Remarch Centre

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The cyclization of peptides and depsipep
The cyclization of peptides and depsipeptides
โœ Dr John S. Davies ๐Ÿ“‚ Article ๐Ÿ“… 2003 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 423 KB

Constricting the peptide backbone into a more defined conformational form through cyclization is an activity evolved in nature and in synthetic work, the latter straddling only the most recent decades. The resulting conformational constraints increase the probability of an optimum response with bio-