๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

The cyclization of peptides and depsipeptides

โœ Scribed by Dr John S. Davies

Book ID
105360306
Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
423 KB
Volume
9
Category
Article
ISSN
1075-2617

No coin nor oath required. For personal study only.

โœฆ Synopsis

Constricting the peptide backbone into a more defined conformational form through cyclization is an activity evolved in nature and in synthetic work, the latter straddling only the most recent decades. The resulting conformational constraints increase the probability of an optimum response with bio-receptors. The purpose of this review is to highlight developments that have proved to be reasonably efficient in the macrocyclization of linear precursors into cyclic peptides and depsipeptides.

๐Ÿ“œ SIMILAR VOLUMES

ChemInform Abstract: Synthesis of Cyclic
ChemInform Abstract: Synthesis of Cyclic Depsipeptides and Peptides via Direct Amide Cyclization.
โœ J. M. VILLALGORDO; H. HEIMGARTNER ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons โš– 29 KB ๐Ÿ‘ 1 views

Synthesis of Cyclic Depsipeptides and Peptides via Direct Amide Cyclization. -An excellent preparative route to ten-membered peptides is presented consisting of the combination of the so-called azirine/oxazolone method and the acid catalyzed amide cyclization. -(VILLALGORDO, J.