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The Cyclization of Peptides and Depsipeptides

โœ Scribed by John S. Davies


Publisher
John Wiley and Sons
Year
2004
Weight
49 KB
Volume
35
Category
Article
ISSN
0931-7597

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๐Ÿ“œ SIMILAR VOLUMES


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โœ J. M. VILLALGORDO; H. HEIMGARTNER ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons โš– 29 KB ๐Ÿ‘ 1 views

Synthesis of Cyclic Depsipeptides and Peptides via Direct Amide Cyclization. -An excellent preparative route to ten-membered peptides is presented consisting of the combination of the so-called azirine/oxazolone method and the acid catalyzed amide cyclization. -(VILLALGORDO, J.

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## Abstract The synthesis of several 18โ€membered cyclodepsipeptides with an alternating sequence of __ฮฑ,ฮฑ__โ€disubstituted __ฮฑ__โ€amino acids and __ฮฑ__โ€hydroxy acids (compounds **14a**โ€“**14e**) is described. The ring closure __via__ macrolactonization was accomplished by treatment of a diluted suspen