Synthesis of Cyclic Depsipeptides and Peptides via Direct Amide Cyclization. -An excellent preparative route to ten-membered peptides is presented consisting of the combination of the so-called azirine/oxazolone method and the acid catalyzed amide cyclization. -(VILLALGORDO, J.
โฆ LIBER โฆ
The Cyclization of Peptides and Depsipeptides
โ Scribed by John S. Davies
- Publisher
- John Wiley and Sons
- Year
- 2004
- Weight
- 49 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0931-7597
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## Abstract The synthesis of several 18โmembered cyclodepsipeptides with an alternating sequence of __ฮฑ,ฮฑ__โdisubstituted __ฮฑ__โamino acids and __ฮฑ__โhydroxy acids (compounds **14a**โ**14e**) is described. The ring closure __via__ macrolactonization was accomplished by treatment of a diluted suspen