The use of free β-hCG in antenatal screening for Down's syndrome
✍ Scribed by N. Wald; J. Densem; R. Stone; R. Cheng
- Book ID
- 118892399
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 269 KB
- Volume
- 44
- Category
- Article
- ISSN
- 0020-7292
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Published studies have reached varying conclusions as to the benefit of replacing human chorionic gonadotropin (hCG) measurements with the free -subunit of hCG (the free -subunit) for Down syndrome screening. One study reports 14 per cent higher detection for the free -subunit, while another finds a
Human chorionic gonadotropin (hCG) free beta-subunit levels were determined in 709 control and 13 Down syndrome urine samples from the second trimester of pregnancy. Results were normalized to urine creatinine concentration and converted to multiples of the unaffected pregnancy medium (MOM). The con