Free β-hCG Subunit Versus Intact hCG in Down Syndrome Screening
✍ Scribed by Katharine D Wenstrom MD; John Owen MD; D.C Chu PhD; Larry Boots PhD
- Book ID
- 117192388
- Publisher
- Lippincott Williams and Wilkins
- Year
- 1997
- Tongue
- English
- Weight
- 277 KB
- Volume
- 90
- Category
- Article
- ISSN
- 0029-7844
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
Published studies have reached varying conclusions as to the benefit of replacing human chorionic gonadotropin (hCG) measurements with the free -subunit of hCG (the free -subunit) for Down syndrome screening. One study reports 14 per cent higher detection for the free -subunit, while another finds a
Human chorionic gonadotropin (hCG) free beta-subunit levels were determined in 709 control and 13 Down syndrome urine samples from the second trimester of pregnancy. Results were normalized to urine creatinine concentration and converted to multiples of the unaffected pregnancy medium (MOM). The con
Hyperglycosylated hCG (H-hCG) is a minor variant of hCG with abnormal oligosaccharide side chains. It is the principal gonadotropin detected in the serum and urine of patients with gestational choriocarcinoma. A monoclonal antibody was produced against this antigen and an immunoassay developed. Leve