𝔖 Bobbio Scriptorium
✦   LIBER   ✦

The use of biosensor technology for the engineering of antibodies and enzymes

✍ Scribed by Adrian Huber; Salvatore Demartis; Dario Neri

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
495 KB
Volume
12
Category
Article
ISSN
0952-3499

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✦ Synopsis

Recently developed scientific instrumentation featuring surface plasmon resonance detection allows the detection of biomolecular interactions in real time and without chemical modification of the binding partners. These biosensors are proving invaluable tools in protein engineering, particularly in research aimed at the isolation and improvement of protein binders and catalysts from macromolecular repertoires containing billions of individual members. This article reviews the use of biosensor technology for the isolation and characterization of engineered antibodies and enzymes.

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