𝔖 Bobbio Scriptorium
✦   LIBER   ✦

The use of angiotensin converting enzyme inhibitors in general practice—appropriate or inappropriate?

✍ Scribed by J. P. Connolly; B. Silke; H. McGavock; K. Wilson-Davies


Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
106 KB
Volume
7
Category
Article
ISSN
1053-8569

No coin nor oath required. For personal study only.

✦ Synopsis


Aims Ð To evaluate the pattern of prescribing of angiotensin-converting enzyme (ACE) inhibitors in general practice, related to the primary clinical diagnosis and concomitant medication.

Design Ð A descriptive survey of general practitioners' prescribing habits, presumptive diagnosis and patient demography over a period of 2 weeks in April 1994.

Setting Ð A strati®ed quota sample of 22 practices in Northern Ireland.

Results Ð The major clinical indication for the use of ACE inhibitors was essential hypertension (61.5%) with only a minority usage (19.9%) in congestive heart failure. Co-prescription of drugs with potential for interaction with angiotensin-converting enzyme inhibitors was not uncommon (16.7%). Of the 353 patients with a diagnosis of congestive heart failure, only 64 (18.1%) were receiving ACE inhibitors. The dosages used were lower than recommended for this indication. A signi®cantly higher proportion of elderly patients with heart failure were prescribed hypnotic drugs (14.7% versus 8.3%; p 5 0.001) and had the co-existence of insomnia (11.8% versus 6.9%;p 5 0.001) compared to patients without heart failure.

Conclusions Ð ACE inhibitors were underused in the treatment of congestive heart failure, and were often prescribed in suboptimal dosages. The frequent concurrent prescription of hypnotics and the co-existence of insomnia in heart failure may re¯ect this therapeutic strategy.


📜 SIMILAR VOLUMES


The absence of a pharmacokinetic interac
✍ A. Sioufi; F. Pommier; N. Gauducheau; J. Godbillon; L. Choi; V. John 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 English ⚖ 491 KB 👁 1 views

Potential effects of the coadministration of single doses of aspirin (325mg) and of benazepril hydrochloride (20 mg) on the pharmacokinetics and the metabolism of these two drugs were evaluated in 12 healthy subjects. Plasma concentration profiles of benazepril, its active metabolite benazeprilat, a

Effects of treatment with angiotensin-co
✍ Masatoshi Yamamoto; Mitsumine Fukui; Ichiyu Shou; Li Ning Wang; Keiko Sekizuka; 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 244 KB 👁 2 views

The aim of this study was to determine if treatment with angiotensin-converting enzyme inhibitors (ACEI) or angiotensin II receptor antagonists (AIIRA) might decrease urinary albumin excretion and prevent glomerular enlargement and glomerulosclerosis in subtotal (5/6) nephrectomized rats. Morphometr

The Effect of an Angiotensin Converting
✍ Yosipovitch, G.; Schneiderman, J.; Erman, A.; Chetrit, A.; Milo, G.; Boner, G.; 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 75 KB 👁 2 views

Patients with longstanding insulin-dependent (Type 1) diabetes mellitus (IDDM) are reported to have microvascular complications in most capillary beds. The microvascular hyperaemia of the skin in normoalbuminuric and microalbuminuric IDDM patients and healthy volunteers was measured with laser Doppl

No association of an insertion/deletion
✍ Furlong, Robert A. ;Keramatipour, Mohammad ;Ho, Luk W. ;Rubinsztein, Judy S. ;Mi 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 71 KB 👁 2 views

A recent Japanese study on the angiotensin I converting enzyme gene (ACE) insertion/ deletion polymorphism reported that both the D allele (P < 0.02) and the DD genotype (P < 0.002) were significantly more frequent in affective disorder cases than in controls [Arinami et al., 1996: Biol Psychiatry 4