✦ LIBER ✦

No association of an insertion/deletion polymorphism in the angiotensin I converting enzyme gene with bipolar or unipolar affective disorders

✍ Scribed by Furlong, Robert A. ;Keramatipour, Mohammad ;Ho, Luk W. ;Rubinsztein, Judy S. ;Michael, Albert ;Walsh, Cathy ;Paykel, Eugene S. ;Rubinsztein, David C.

Publisher: John Wiley and Sons
Year: 2000
Tongue: English
Weight: 71 KB
Volume: 96
Category: Article
ISSN: 0148-7299
DOI: 10.1002/1096-8628(20001204)96:6<733::aid-ajmg7>3.0.co;2-8

No coin nor oath required. For personal study only.

✦ Synopsis

A recent Japanese study on the angiotensin I converting enzyme gene (ACE) insertion/ deletion polymorphism reported that both the D allele (P < 0.02) and the DD genotype (P < 0.002) were significantly more frequent in affective disorder cases than in controls [Arinami et al., 1996: Biol Psychiatry 40: 1122-1127]. A replication study was performed by using 157 bipolar I affective disorder cases, 169 major depressive disorder cases, and 313 controls. No significant association with this polymorphism was found in either disorder or in a combined affective disorder group. These results do not support the ACE gene having a major role in the etiology of either bipolar or unipolar affective disorders. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 96:733-735, 2000.

📜 SIMILAR VOLUMES

No association of the tryptophan hydroxy

No association of the tryptophan hydroxylase gene with bipolar affective disorder, unipolar affective disorder, or suicidal behaviour in major affective disorder

✍ Furlong, Robert A.; Ho, Luk; Rubinsztein, Judy S.; Walsh, Cathy; Paykel, Eugene 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 10 KB 👁 2 views

Tryptophan hydroxylase (TPH) is the rate-limiting enzyme in the synthesis of 5-hydroxytryptamine (5-HT). An association study in bipolar affective disorder I or unipolar major affective disorder was performed by using a Bfa I restriction site polymorphism within intron 7 of the tryptophan hydroxylas

No association of a functional polymorph

No association of a functional polymorphism in the dopamine D2 receptor promoter region with bipolar or unipolar affective disorders

✍ Furlong, Robert A.; Coleman, Tabytha A.; Ho, Luk; Rubinsztein, Judy S.; Walsh, C 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 14 KB 👁 2 views

The dopaminergic system, along with the serotonergic and noradrenergic systems, has been implicated in the etiology of mood disorders. An association study of a functional variant in the promoter region of the dopamine D2 receptor (DRD2) with bipolar affective disorder I or unipolar major affective