The urokinase plasminogen activator system as a target for prognostic studies in breast cancer
✍ Scribed by Ross W. Stephens; Nils Brünner; Fritz Jänicke; Manfred Schmitt
- Book ID
- 110232232
- Publisher
- Springer US
- Year
- 1998
- Tongue
- English
- Weight
- 956 KB
- Volume
- 52
- Category
- Article
- ISSN
- 0167-6806
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The urokinase-type plasminogen activator (u-PA) system consists of the serine proteinases plasmin and u-PA; the serpin inhibitors a 2 -anti-plasmin, PAI-1 and PAI-2; and the u-PA receptor (u-PAR). Two lines of evidence have strongly suggested an important and apparently causal role for the u-PA syst
## Urokinase -type plasminogen activator (u-PA) is thought to be implicated in cancer invasion and metastasis. The aim of this study was to determine whether the u-PA content of cancer tissue is a prognostic factor in bladder cancer. Tissue samples from 46 patients with bladder cancer were assesse