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The ubiquitin–proteasome system and assays to determine responses to inhibitors

✍ Scribed by Tsvetkov, Lyuben; Nanjundan, Meera; Domino, Maria; Daniel, Kenyon G


Book ID
115438923
Publisher
Informa plc
Year
2010
Tongue
English
Weight
706 KB
Volume
5
Category
Article
ISSN
1746-0441

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## Abstract The lysosomal apoptosis pathway is a potentially interesting therapeutic target. Since apoptosis involving the lysosomal pathway has been described to involve cathepsins, we screened a drug library for agents that induce cathepsin‐dependent apoptosis. Using pharmacological inhibitors an