✦ LIBER ✦

The Two Period Binary Response Cross-Over Trial

✍ Scribed by Dr. N. J. D. Nagelkerke; A. A. M. Hart; J. Oosting

Publisher: John Wiley and Sons
Year: 1986
Tongue: English
Weight: 368 KB
Volume: 28
Category: Article
ISSN: 0323-3847
DOI: 10.1002/bimj.4710280715

No coin nor oath required. For personal study only.

✦ Synopsis

The cross-over deeign for clinical trials when responses are binary is discuseed. Three testa whicli have been proposed for the analysis of this problem are compared by an Bssessment of their Baeumptione. A simple test to cetablish whether it is appropriate to include observetione from the second period is presented.

Key wwh: Cross-over design ; Clinical trials ; Hypothesis testing ; Carry-over effects.

📜 SIMILAR VOLUMES

Binary Responses and the Three-period Cr

Binary Responses and the Three-period Cross-over

✍ G. H. Morrey 📂 Article 📅 1989 🏛 John Wiley and Sons 🌐 English ⚖ 478 KB

Problems with carry-over effects in the simple two-period crowover have lead to interest in more complex crow-over designs. A method for analping the optimum two-treatment three-period design with binaryresponse variables is given by making a simple extension to Gart's logistic model.The method give

Testing Hypotheses in the Two-period Cha

Testing Hypotheses in the Two-period Change-over with Binary Data

✍ Dr. H. Zimmermann; V. Rahlfs 📂 Article 📅 1978 🏛 John Wiley and Sons 🌐 English ⚖ 350 KB

The paper propowe a general model for analyeizing two-period change-over deaigne with binary data. The model includes testa for carry-over effecta, treatment and period effede in analogy to the well-known ANOVA-model for oontinuoue data. Minimum modified Xtetatistice are derived and formulae for dea

STATISTICAL METHODS FOR TWO-SEQUENCE THR

STATISTICAL METHODS FOR TWO-SEQUENCE THREE-PERIOD CROSS-OVER DESIGNS WITH INCOMPLETE DATA

✍ SHEIN-CHUNG CHOW; JUN SHAO 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 211 KB 👁 1 views

In clinical trials, and in bioavailability and bioequivalence studies, one often encounters replicate cross-over designs such as a two-sequence three-period cross-over design to assess treatment and carry-over effects of two formulations of a drug product. Because of the potential dropout (or for so

ROBUST PROCEDURES FOR ANALYSING A TWO-PE

ROBUST PROCEDURES FOR ANALYSING A TWO-PERIOD CROSS-OVER DESIGN WITH BASELINE MEASUREMENTS

✍ K. T. TSAI; H. L. PATEL 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 617 KB

Pate1 analysed a two-period cross-over design with baseline measurements assuming bivariate normality for the joint distribution of the period responses. In this paper, we propose non-parametric methods for analysing this design, including the use of the Wilcoxon rank sum test to derive the prelimin

Randomization and Additivity in the Two-

Randomization and Additivity in the Two-Period Crossover Clinicial Trial

✍ Prof. Richard McHugh; Orlando Gomez-Marin 📂 Article 📅 1987 🏛 John Wiley and Sons 🌐 English ⚖ 427 KB 👁 1 views

I n certain a r m of medical reeearch, the two-period CrOBBOVer deaign is a frequent choice for comparing treatmentsA and B in a randomized clinicel trial. Earlier work by Grizzle and by Brown WBB baaed upon a parametric theory linear model. Recenfly, the present authom employed D. R. Cox's additive

Non-Parametric Methods for the 2-Period-

Non-Parametric Methods for the 2-Period-Cross-Over Design Under Weak Model Assumptions

✍ Prof. Dr. E. Brunner; Dr. N. Neumann 📂 Article 📅 1987 🏛 John Wiley and Sons 🌐 English ⚖ 571 KB

X nonperametric analysis for the two period cross-over design has first been suggested by KOCH (1972) and has been diecussed by HILLS and ABMITAGE (1979). As known rank teats on s u m or differenof the data are applied in this procedure, the results on the one hand am not invariant under monotonous