The cross-over deeign for clinical trials when responses are binary is discuseed. Three testa whicli have been proposed for the analysis of this problem are compared by an Bssessment of their Baeumptione. A simple test to cetablish whether it is appropriate to include observetione from the second pe
Binary Responses and the Three-period Cross-over
โ Scribed by G. H. Morrey
- Publisher
- John Wiley and Sons
- Year
- 1989
- Tongue
- English
- Weight
- 478 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0323-3847
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โฆ Synopsis
Problems with carry-over effects in the simple two-period crowover have lead to interest in more complex crow-over designs. A method for analping the optimum two-treatment three-period design with binaryresponse variables is given by making a simple extension to Gart's logistic model.The method gives independent testa for. and estimates of the difference in treatment and firsborder carry-over effecta. An example of the analyeis ie given, wing t h e loglinear models facility in GLIM.
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