𝔖 Bobbio Scriptorium
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Randomization and Additivity in the Two-Period Crossover Clinicial Trial

✍ Scribed by Prof. Richard McHugh; Orlando Gomez-Marin

Publisher
John Wiley and Sons
Year
1987
Tongue
English
Weight
427 KB
Volume
29
Category
Article
ISSN
0323-3847

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✦ Synopsis

I n certain a r m of medical reeearch, the two-period CrOBBOVer deaign is a frequent choice for comparing treatmentsA and B in a randomized clinicel trial. Earlier work by Grizzle and by Brown WBB baaed upon a parametric theory linear model. Recenfly, the present authom employed D. R. Cox's additive randomihtion models and, for the CBBB of zero miduel effect, found a discrepancy between it and the parametrio model with respeat to the precision of period effecta. In the present note, thie divergence irr accounted for by allowing for the poaaibility of non-additivity through the urn of a completely general randomization model. It ie concluded that the strudure of the crossover design it3 euch that use of the parametric theory linear model is required if a single, consistent model is desired.

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