We have recently reported that the tricyclic antidepressants (TCAs) imipramine, clomipramine, and citalopram induce apoptosis in human peripheral lymphocytes. This system is well suited for studies on the pathophysiology/physiology of apoptosis regulation. Apoptosis was determined using both DNA gel
The Tricyclic Antidepressants Clomipramine and Citalopram Induce Apoptosis in Cultured Human Lymphocytes
✍ Scribed by Zhenlei Xia; Joseph W. Depierre; Lennart Nässberger
- Book ID
- 118110197
- Publisher
- Pharmaceutical Press
- Year
- 1996
- Tongue
- English
- Weight
- 223 KB
- Volume
- 48
- Category
- Article
- ISSN
- 2042-7158
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Some widely used antidepressants such as imipramine, clomipramine, and citalopram have been found to possess antineoplastic effects. In the present study, these compounds were found to induce apoptotic cell death in human acute myeloid leukemia HL-60 cells. Apoptosis induced by the antidepressants w
Tricyclic antidepressants (TCAs) have been shown to induce apoptosis in human lymphocytes. In the present report, we investigated in parallel the regulation of the three oncogenes bcl-2, c-myc, and Fas. A reduction in c-myc and bcl-2 levels of 35-40% and 22-27%, respectively, was observed. On the ot
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