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Dysregulation of bcl-2, c-myc, and Fas expression during tricyclic antidepressant-induced apoptosis in human peripheral lymphocytes

✍ Scribed by Xia, Zhenlei ;DePierre, Joseph W. ;Nässberger, Lennart

Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
65 KB
Volume
11
Category
Article
ISSN
0887-2082

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✦ Synopsis

Tricyclic antidepressants (TCAs) have been shown to induce apoptosis in human lymphocytes. In the present report, we investigated in parallel the regulation of the three oncogenes bcl-2, c-myc, and Fas. A reduction in c-myc and bcl-2 levels of 35-40% and 22-27%, respectively, was observed. On the other hand, Fas expression on the outer surface of the plasma membrane was increased up to 31%. In conclusion, bcl-2, c-myc, and Fas are undergoing dysregulation due to TCA-induced apoptosis.

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