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The transcriptional co-activator proteins p300 and CBP stimulate adenovirus E1A conserved region 1 transactivation-independent of a direct interaction

✍ Scribed by Mattias Mannervik; Göran Akusjärvi


Book ID
117108080
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
733 KB
Volume
414
Category
Article
ISSN
0014-5793

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Roles of p300, pocket proteins, and hTBP
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The conserved region 1 and the extreme N-terminus of adenoviral oncoprotein E1A are essential for transforming activity. They also play roles in the interaction of E1A with p300/CBP and pRb and are involved in both transactivation and repression of host gene expression. It was reported recently that