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Inhibition of p53-mediated transactivation and cell cycle arrest by E1A through its p300/CBP-interacting region

โœ Scribed by Somasundaram, Kumaravel; El-Deiry, Wafik S


Book ID
110060625
Publisher
Nature Publishing Group
Year
1997
Tongue
English
Weight
927 KB
Volume
14
Category
Article
ISSN
0950-9232

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The conserved region 1 and the extreme N-terminus of adenoviral oncoprotein E1A are essential for transforming activity. They also play roles in the interaction of E1A with p300/CBP and pRb and are involved in both transactivation and repression of host gene expression. It was reported recently that