Compounds 7-8, monoterpenic analogues of the marine metabolites puupehenone (1) and puupehedione (2), were prepared from the easily available gcyclocitral(10) and the aryllithium derived from 11 and 12.8 showed antitumoral activity 4 -10 times higher than that for the natural products.
✦ LIBER ✦
The total synthesis of (±)-puupehenone
✍ Scribed by G.L. Trammell
- Publisher
- Elsevier Science
- Year
- 1978
- Tongue
- French
- Weight
- 183 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0040-4039
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