Enantiospecific synthesis of (+)-puupehenone from (−)-sclareol and protocatechualdehyde
✍ Scribed by Alejandro F. Barrero; Enrique J. Alvarez-Manzaneda; Rachid Chahboun
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- French
- Weight
- 246 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
The fmt enantiospecificsynthesisof the cholesterolester mansferprotein (CETP)inhibitorwiedendiol-B(1) is described.The drimanicsyntbonwas prepared from(-)-sclareol( 4) and (+)-cis-abienol ( 13)by two akernativeroutes.The key steps of the reactionsequencesare the chemo-anddisstereoselectivehydrogenat
Compounds 7-8, monoterpenic analogues of the marine metabolites puupehenone (1) and puupehedione (2), were prepared from the easily available gcyclocitral(10) and the aryllithium derived from 11 and 12.8 showed antitumoral activity 4 -10 times higher than that for the natural products.