Synthesis of monoterpenic analogues of puupehenone and puupehedione

✍ Scribed by Alejandro F. Barrero; Enrique J. Alvarez-Manzaneda; M. Mar Herrador; Mónica V. Valdivia; Rachid Chahboun

• Publisher: Elsevier Science
• Year: 1998
• Tongue: French
• Weight: 259 KB
• Volume: 39
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(98)00216-0

✦ Synopsis

Compounds 7-8, monoterpenic analogues of the marine metabolites puupehenone (1) and puupehedione (2), were prepared from the easily available gcyclocitral(10) and the aryllithium derived from 11 and 12.8 showed antitumoral activity 4 -10 times higher than that for the natural products.