𝔖 Bobbio Scriptorium
✦   LIBER   ✦

The therapeutic significance of concomitant antitumor immunity

✍ Scribed by Robert J. North

Publisher
Springer-Verlag
Year
1984
Tongue
English
Weight
624 KB
Volume
18
Category
Article
ISSN
0340-7004

No coin nor oath required. For personal study only.

✦ Synopsis

It is shown that progressive growth of the SA1 sarcoma in its semisyngeneic AB6F1 host results in the generation of concomitant immunity to growth of a tumor challenge implant, and in the generation of T cells in the spleen capable, on passive transfer, of causing regression of an established tumor in gamma-irradiated recipients, but not in normal recipients. T cells that passively transferred concomitant immunity against an established tumor were first generated around day 6 of tumor growth, reached peak numbers on day 9, and slowly decreased in number thereafter. They were of the Ly-1-2+ phenotype, in that they were functionally eliminated by treatment with monoclonal anti-Ly-2 antibody and complement, but not by treatment with anti-Ly-1 antibody and complement. The paradoxical ability of T cells from a donor with a relatively large tumor to cause the regression of a tumor in sublethally gamma-irradiated recipients is explained with reference to the facts that the recipient tumor was only half as large as the donor tumor at the time of passive transfer, and that the recipient was incapable of generating suppressor T cells that would function to inhibit the expression of adoptive immunity.

📜 SIMILAR VOLUMES

The therapeutic significance of concomit
The therapeutic significance of concomitant antitumor immunity
✍ Robert J. North 📂 Article 📅 1984 🏛 Springer-Verlag 🌐 English ⚖ 565 KB

Intravenous injection of 50 micrograms bacterial endotoxin can cause complete regression of an established SA1 sarcoma, but not if the tumor ir growing in mice that are incapable of generating concomitant immunity because they have been made T cell-deficient by thymectomy and gamma-radiation (TXB mi

On the mechanism of tumor ‘concomitant i
On the mechanism of tumor ‘concomitant immunity’
✍ Eliezer Gorelik; Shraga Segal; Michael Feldman 📂 Article 📅 1981 🏛 John Wiley and Sons 🌐 French ⚖ 894 KB

## Abstract Experiments were carried out relevant to the mechanisms involved in tumor ‘concomitant immunity’. Mice bearing 3LL, B16, EL4 or the methylcholanthrene‐induced T‐10 tumors were capable of completely suppressing the growth of a subsequent intra footpad graft of tumor cells. The observed i

Suppression of generation of concomitant
Suppression of generation of concomitant antitumor immunity by passively transferred suppressor T cells from tumor-bearing donors
✍ Isia Bursuker; Robert J. North 📂 Article 📅 1985 🏛 Springer-Verlag 🌐 English ⚖ 419 KB

## Infusion of normal recipient mice with suppressor T cells from donors bearing a progressive Meth A fibrosarcoma results in a diminished capacity of the recipients to generate concomitant and postexcision antitumor immunity. The passive transfer of suppressor cells which prevented the generation o

Induction of protective and therapeutic
Induction of protective and therapeutic antitumor immunity by a DNA vaccine with a glioma antigen, SOX6
✍ Ryo Ueda; Eiko Kinoshita; Rena Ito; Takeshi Kawase; Yutaka Kawakami; Masahiro To 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 French ⚖ 219 KB

## Abstract We previously reported identifying SOX6 as a glioma antigen by serological screening using a testis cDNA library. Its preferential expression and frequent IgG responses in glioma patients indicate that SOX6 may be a useful target for immunotherapy. To examine whether cytotoxic T‐lymphoc