✦ LIBER ✦
Suppression of generation of concomitant antitumor immunity by passively transferred suppressor T cells from tumor-bearing donors
✍ Scribed by Isia Bursuker; Robert J. North
- Publisher
- Springer-Verlag
- Year
- 1985
- Tongue
- English
- Weight
- 419 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0340-7004
No coin nor oath required. For personal study only.
✦ Synopsis
Infusion of normal recipient mice with suppressor T cells from donors bearing a progressive Meth A fibrosarcoma results in a diminished capacity of the recipients to generate concomitant and postexcision antitumor immunity. The passive transfer of suppressor cells which prevented the generation of immunity to the Meth A fibrosarcoma did not affect the capacity of the recipients to reject an allogeneic tumor.
The data provides direct evidence in support of the hypothesis that suppressor T cells, generated at later stages of growth of Meth A fibrosarcoma, function to down-regulate an already acquired mechanism of concomitant immunity.