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The t(6;11)(q27;q23) translocation in acute leukemia: a laboratory and clinical study of 30 cases

✍ Scribed by Martineau, M; Berger, R; Lillington, D M; Moorman, A V; Secker-Walker, L M


Book ID
110053837
Publisher
Nature Publishing Group
Year
1998
Tongue
English
Weight
40 KB
Volume
12
Category
Article
ISSN
0887-6924

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A new case of translocation t(6;11)(q21;q23) in a patient with therapy-related acute myeloblastic leukemia is reported. The translocation results in fusion of the MLL and AF6q21 genes. The breakpoint with AF6q21 is located within the sequences encoding the AF6q21 fork head motif. The similar locatio

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## Abstract Thirteen cosmid probes were mapped on the long arm of chromosome 11 between 11q22 and 11q24 by nonradioactive in situ hybridization. Starting with these localizations and those of other probes mapped to 11q23, four acute leukemias with translocations involving 11q23 were studied with th

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Chromosomal analysis of acute monocytic leukemia cells in a female infant revealed a t(6;11)(q27;q23) translocation. Southern blot analysis with a cDNA probe of the MLL gene at chromosome band 11q23 indicated that the breakpoint was in an 8.3-kb BamHI fragment that contained exons 5-11 of the MLL ge

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✍ William Blum; Krzysztof MrΓ³zek; Amy S. Ruppert; Andrew J. Carroll; Kathleen W. R πŸ“‚ Article πŸ“… 2004 πŸ› John Wiley and Sons 🌐 English βš– 121 KB

## Abstract ## BACKGROUND Acute myeloid leukemia (AML) with t(6;11)(q27;q23) is a well established but rare entity, and few studies have reported the full clinical, hematologic, and outcome data of patients with this disease. ## METHODS To characterize the features of t(6;11) AML, the authors se