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The 11q23 breakpoint in acute leukemia with t(11;19)(q23;p13) is distal to those of t(4;11), t(6;11) and t(9;11)

✍ Scribed by Dorra Cherif; Hera Der-Sarkissian; Josette Derré; Roland Berger; Takashi Tokino; Yusuke Nakamura

Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
544 KB
Volume
4
Category
Article
ISSN
1045-2257

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✦ Synopsis

Abstract

Thirteen cosmid probes were mapped on the long arm of chromosome 11 between 11q22 and 11q24 by nonradioactive in situ hybridization. Starting with these localizations and those of other probes mapped to 11q23, four acute leukemias with translocations involving 11q23 were studied with the same method. The translocation breakpoints of the t(4;11)(q21;q23), t(6;11)(q27;q23), t(9;11)(p21–p22;q23), and t(11;19)(q23;p13) were confirmed to be distal to CD3D. The probe cC11 1–304 was proximal to the t(11;19) breakpoint while distal to the breakpoints of the other rearrangements. In view of the diversity of chromosomal abnormalities involving band 11q23, our finding extends the molecular heterogeneity of the breakpoint localization in leukemias with rearrangements involving 11q23.

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